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Biomimetic Materials and Tissue Engineering Laboratory, Department of Chemical Engineering, University of South Carolina, Swearingen Engineering Center, Rm 2C11, Columbia, USA E-mail: [email protected] Fax: 1-803-777-0973 Tel: 1-803-777-8022 Articular cartilage is organized into multiple zones including superficial, middle and calcified zones with distinct cellular and extracellular components to impart lubrication, compressive strength, and rigidity for load transmission to bone, respectively.

Human mesenchymal stem cells (h MSCs) were encapsulated in acrylate-functionalized lactide-chain-extended polyethylene glycol (SPELA) gels simulating cell density and stiffness of the superficial, middle and calcified zones.

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It is definitely not a reason for my work but I feel very strongly that things should be real. A personal connection between people rather than the subject.” For some people, they are a step too far. “It was a very personal project but I think part of the reason may be that people are looking for something real and more authentic – not just in art but in the way we want to know what’s in our food and how we live our lives.

“Disgusting”, “Revolting”, “I don’t want to see naked old bags.” Well, best look away, people, because, guess what, it’s going to happen to you. No matter what their age or sex, so many people have responded in a really human way.” I think that’s why I got so excited about them too.

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